Anandaraj made his debut in Oru Thalai Ragam (1980), but his breakthrough came with En Thangai Kalyani (1988), where he played a menacing antagonist. Throughout the late 1980s and 1990s, he became one of the most sought-after villains in Tamil cinema, appearing alongside leading stars such as Rajinikanth, Kamal Haasan, and Vijayakanth. His deep voice, intense expressions, and imposing physique made him a natural fit for villainous and character roles.
In recent years, Anandaraj has reinvented himself by taking on comedic and supporting roles, showcasing his versatility beyond negative characters. Films like Mundasupatti (2014), Naanum Rowdy Dhaan (2015), and Master (2021) highlighted his ability to adapt to changing trends in cinema. His career longevity and ability to evolve with time have made him a respected figure in the industry.