Indrajith made his debut as a child artist in Padayani (1986). After completing his education—including a B.Tech in Computer Science Engineering from Rajaas Engineering College—he briefly worked as a software professional before pursuing acting full-time. His breakthrough came with the villain role of Eapen Pappachi in Meesa Madhavan (2002), which established him as a versatile performer.
Since then, he has starred in over 90 films, ranging from commercial blockbusters to critically acclaimed projects. His notable works include Classmates (2006), Ee Adutha Kaalathu (2012), Amen (2013), Left Right Left (2013), Lucifer (2019), Virus (2019), and Kurup (2021). He is admired for seamlessly shifting between lead, supporting, and antagonist roles, making him one of Malayalam cinema’s most respected actors.