Lee Do-hyun made his acting debut in 2017 with Prison Playbook, portraying the younger version of Jung Kyung-ho’s character. His breakthrough came in 2019 with Hotel del Luna, where he played Go Chung-myung, earning recognition for his emotional performance. He quickly transitioned to lead roles, starring in 18 Again (2020), which won him the Best New Actor award at the Baeksang Arts Awards.
He continued to build his career with diverse roles in Sweet Home (2020–2024), Youth of May (2021), Melancholia (2021), and Netflix’s The Glory (2022–2023). In 2023, he starred in The Good Bad Mother, further solidifying his reputation as one of Korea’s most versatile actors. His film debut came with Exhuma (2024), showcasing his ability to adapt to both television and cinema.