Mona Singh began her career with the iconic television show Jassi Jaissi Koi Nahin (2003–2006), where she played Jasmeet Walia, a character that became a cultural phenomenon. Her portrayal won her several awards and established her as one of the most recognizable faces on Indian television. She later participated in and won the first season of Jhalak Dikhhla Jaa, showcasing her versatility beyond acting.
She made her Bollywood debut with 3 Idiots (2009), playing Mona Sahastrabuddhe, and later appeared in films like Utt Pataang and Zed Plus. In recent years, she has gained acclaim in digital projects such as Yeh Meri Family (2018) and Made in Heaven (2019). Her career reflects adaptability across mediums, making her a respected figure in Indian entertainment.