Murali Sharma began his acting journey in Hindi films and television before establishing himself in South Indian cinema. His breakthrough came with Main Hoon Na (2004), where he played a memorable supporting role. He later gained recognition in Telugu films such as Athidi (2007), Kantri (2008), and Ala Vaikunthapurramuloo (2020), showcasing his versatility as a character actor. His performances often bring depth and authenticity to the films he is part of.
Beyond cinema, Murali Sharma has also worked in television and is known for his disciplined approach to acting. He married actress Ashwini Kalsekar in 2009, and the couple is considered one of the respected pairs in the industry. His dedication, adaptability, and strong screen presence have earned him awards including the Nandi Award for Best Villain and the SIIMA Award for Best Supporting Actor.