Mysskin began his career assisting director Kathir before making his directorial debut with Chithiram Pesuthadi (2006), which became a sleeper hit. His second film, Anjathe (2008), cemented his reputation as a bold storyteller, blending gritty realism with stylized filmmaking. Over the years, he has directed critically acclaimed films such as Yuddham Sei (2011), Onaayum Aattukkuttiyum (2013), and Psycho (2020), each noted for their dark themes and innovative narrative techniques.
Apart from directing, Mysskin has also acted in several films, including Super Deluxe (2019) and Savarakathi (2018). His screen presence, combined with his philosophical outlook, has made him a respected figure both behind and in front of the camera. Known for his deep interest in literature and philosophy, Mysskin often infuses his films with existential questions, making his work stand out in contemporary Tamil cinema.