Raghu Babu entered the Telugu film industry in the late 1980s, making his debut with Dongalu Unnaru Jagratha (1990). Over the years, he transitioned into comedy roles and became one of the most dependable supporting actors in Telugu cinema. His unique mannerisms, witty dialogue delivery, and ability to adapt to diverse roles earned him recognition and respect. He has acted in hundreds of films, often playing memorable comic characters alongside leading stars.
Apart from his acting career, Raghu Babu has also been active in industry organizations. He served as the General Secretary of the Movie Artists Association (MAA), contributing to the welfare of fellow artists. His long-standing career and dedication to cinema have made him a household name in Andhra Pradesh and Telangana, and he continues to be a prominent figure in Tollywood.