Sana Saeed was born on 22 September 1988 in Mumbai, Maharashtra. She began her career at the age of 10, playing the role of Anjali Khanna in Kuch Kuch Hota Hai (1998), which made her a household name. She continued to appear in films as a child artist, including Har Dil Jo Pyar Karega (2000) and Badal (2000).
After completing her education, Sana returned to acting as an adult with Karan Johar’s Student of the Year (2012), where she played Tanya Israni. She also appeared in television shows such as Babul Ka Aangann Chootey Na and Lo Ho Gayi Pooja Iss Ghar Ki. In addition, she participated in reality shows like Jhalak Dikhhla Jaa 6 (2013), Nach Baliye 7 (2015), and Fear Factor: Khatron Ke Khiladi 7 (2016).