Santosh Juvekar began his career in Marathi theatre before moving into television and films. His early recognition came from the TV serial Ya Gojirvanya Gharat (2004), which made him a familiar face in Marathi households. He later transitioned into films, appearing in Blind Game (2006) and gaining popularity with Zenda (2010), where his performance was widely appreciated.
Over the years, Juvekar has acted in notable films such as Morya (2011), Matter (2012), Rege (2014), and Gadbad Gondhal (2017). He has also been active in theatre, continuing to balance stage and screen work. His versatility allows him to portray both intense and light-hearted characters, making him one of the respected actors in Marathi entertainment.