Trinadha Rao Nakkina began his career in Telugu cinema with Mem Vayasuku Vacham (2012), which introduced him as a director with a youthful storytelling style. Though his debut did not achieve major commercial success, it set the stage for his later works. His breakthrough came with Cinema Choopistha Mava (2015), starring Raj Tarun and Avika Gor, which became a surprise hit and established him as a director capable of connecting with younger audiences.
Following this success, he directed Nenu Local (2017), starring Nani, which was a box office hit and cemented his reputation in the industry. He continued with films like Hello Guru Prema Kosame (2018) and Dhamaka (2022), the latter being a major commercial success with Ravi Teja. His upcoming projects include Mazaka (2025) and Nenu Ready. Known for his commercial sensibilities, Trinadha Rao balances youthful romance with mass entertainment in his films.